首页> ChemMedChem> An Imidazo[2,1-b][1,3,4]thiadiazole Derivative Inhibits the Virulence Factor α-Hemolysin by Blocking the Pullout of Its Stem Domain.

An Imidazo[2,1-b][1,3,4]thiadiazole Derivative Inhibits the Virulence Factor α-Hemolysin by Blocking the Pullout of Its Stem Domain.

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第一作者： Vadim S,Korotkov

第一单位： Chemical Biology, Helmholtz Centre for Infection Research, Braunschweig, Germany.

作者： Vadim S,Korotkov ^[1] ; Peer,Lukat ^[2] ; Raffaella,Di Lucrezia ^[3] ; Aditya,Shekhar ^[4] ; Carsten,Degenhart ^[3] ; Randi,Diestel ^[1] ; Ursula,Bilitewski ^[4] ; Klaus,Dinkel ^[3] ; Wulf,Blankenfeldt ^[2] ; Mark,Brönstrup ^[5]

作者单位： Chemical Biology, Helmholtz Centre for Infection Research, Braunschweig, Germany. ^[1] Structure and Function of Proteins, Helmholtz Centre for Infection Research, Braunschweig, Germany. ^[2] Lead Discovery Center, Dortmund, Germany. ^[3] Compound Profiling and Screening, Helmholtz Centre for Infection Research, Braunschweig, Germany. ^[4] Chemical Biology, Helmholtz Centre for Infection Research, Braunschweig, Germany.;German Center for Infection Research (DZIF), Site Hannover-Braunschweig, Germany.;Center of Biomolecular Drug Research (BMWZ), Leibniz Universität, Hannover, Germany. ^[5]

关键词 antibacterials antivirulence high‐throughput screening structural biology structure–activity relationships