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HIV broadly neutralizing antibody escape dynamics drive the outcome of AAV-vectored immunotherapy in humanized mice.

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第一作者： Nicolas M S,Galvez

第一单位： Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA 02139, USA.

作者： Nicolas M S,Galvez ^[1] ; Adam D,Nitido ^[1] ; Seo Bin,Yoo ^[1] ; Yi,Cao ^[1] ; Cailin E,Deal ^[1] ; Christine L,Boutros ^[1] ; Scott W,MacDonald ^[1] ; Yentli E,Soto Albrecht ^[1] ; Evan C,Lam ^[1] ; Maegan L,Sheehan ^[1] ; Dylan,Parsons ^[1] ; Allen Z,Lin ^[1] ; Martin J,Deymier ^[1] ; Jacqueline M,Brady ^[1] ; Benjamin,Moon ^[1] ; Christopher B,Bullock ^[1] ; Serah,Tanno ^[1] ; Amarendra,Pegu ^[2] ; Xuejun,Chen ^[2] ; Cuiping,Liu ^[2] ; Richard A,Koup ^[2] ; John R,Mascola ^[2] ; Vladimir D,Vrbanac ^[1] ; Daniel,Lingwood ^[1] ; Alejandro B,Balazs ^[3]

作者单位： Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA 02139, USA. ^[1] Vaccine Research Center, National Institute of Allergy and Infectious Diseases and National Institutes of Health, Bethesda, MD 20892, USA. ^[2] Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA 02139, USA. Electronic address: abalazs@mgh.harvard.edu. ^[3]

关键词 AAV HIV broadly neutralizing antibody escapability evolution fitness humanized mice resistance vectored immunotherapy