首页> European journal of pharmacology> OTUD3-mediated deubiquitination licenses TEX264 to orchestrate ER-phagy for KDM5B degradation in teniposide lung cancer therapy.

OTUD3-mediated deubiquitination licenses TEX264 to orchestrate ER-phagy for KDM5B degradation in teniposide lung cancer therapy.

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第一作者： Ning,Han

第一单位： Department of Pharmacology, School of Basic Medical Sciences, Wuhan University, Donghu Avenue No.185, Wuhan, 430072, China; Shiyan Key Laboratory of Natural Medicine Nanoformulation Research, Hubei Key Laboratory of Embryonic Stem Cell Research, School of Basic Medical Sciences, Hubei University of Medicine, Renmin Road No. 30, Shiyan, Hubei, 442000, China.

作者： Ning,Han ^[1] ; Xin-Ran,Yu ^[2] ; Liu-Gen,Li ^[1] ; Jun,Hu ^[3] ; Fan,Leng ^[3] ; Lei,Wang ^[2] ; Ting-Ting,Yu ^[4] ; Hua-Zhen,Xu ^[5] ; Hongyao,Huang ^[6] ; Tong-Fei,Li ^[7] ; Xiao,Chen ^[8]

作者单位： Department of Pharmacology, School of Basic Medical Sciences, Wuhan University, Donghu Avenue No.185, Wuhan, 430072, China; Shiyan Key Laboratory of Natural Medicine Nanoformulation Research, Hubei Key Laboratory of Embryonic Stem Cell Research, School of Basic Medical Sciences, Hubei University of Medicine, Renmin Road No. 30, Shiyan, Hubei, 442000, China. ^[1] Shiyan Key Laboratory of Natural Medicine Nanoformulation Research, Hubei Key Laboratory of Embryonic Stem Cell Research, School of Basic Medical Sciences, Hubei University of Medicine, Renmin Road No. 30, Shiyan, Hubei, 442000, China. ^[2] Center for Translational Medicine, Suizhou Hospital, Hubei University of Medicine, Suizhou, Hubei, 441300, China; Shiyan Key Laboratory of Natural Medicine Nanoformulation Research, Hubei Key Laboratory of Embryonic Stem Cell Research, School of Basic Medical Sciences, Hubei University of Medicine, Renmin Road No. 30, Shiyan, Hubei, 442000, China. ^[3] Department of Pathology, Renmin Hospital of Shiyan, Hubei University of Medicine, Shiyan, Hubei, 442000, China. ^[4] Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA. ^[5] Center for Translational Medicine, Suizhou Hospital, Hubei University of Medicine, Suizhou, Hubei, 441300, China. Electronic address: hhy731120hb@sina.com. ^[6] Center for Translational Medicine, Suizhou Hospital, Hubei University of Medicine, Suizhou, Hubei, 441300, China; Shiyan Key Laboratory of Natural Medicine Nanoformulation Research, Hubei Key Laboratory of Embryonic Stem Cell Research, School of Basic Medical Sciences, Hubei University of Medicine, Renmin Road No. 30, Shiyan, Hubei, 442000, China. Electronic address: litongfeihappy@163.com. ^[7] Department of Pharmacology, School of Basic Medical Sciences, Wuhan University, Donghu Avenue No.185, Wuhan, 430072, China. Electronic address: chen-xiao-1976@hotmail.com. ^[8]

关键词 ER-Phagy KDM5B Lung cancer OTUD3 TEX264 Teniposide (Ten)