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A logic-gated trispecific engager enhances macrophage killing of cancer cells in solid tumors.

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第一作者: Xiaotian,Zhao
第一单位: Shandong Key Laboratory of Targeted Drug Delivery and Advanced Pharmaceutics, NMPA Key Laboratory for Technology Research and Evaluation of Drug Products, and Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences; Department of Urology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
作者: Xiaotian,Zhao [1] ; Weiqiang,Jing [2] ; Ganyu,Wang [1] ; Zhanyan,Liu [1] ; Xinxin,Xu [1] ; Maosen,Han [1] ; Zhipeng,Fu [1] ; Yulin,Zhang [3] ; Zuolin,Zheng [1] ; Jing,Zhang [1] ; Longyu,Bo [1] ; Xianghui,Dong [1] ; Caiping,Li [1] ; Yanhua,Sun [4] ; Junfeng,Zhang [5] ; Fabao,Zhao [6] ; Nianzeng,Xing [7] ; Kun,Zhao [8] ; Xinyi,Jiang [9]
作者单位: Shandong Key Laboratory of Targeted Drug Delivery and Advanced Pharmaceutics, NMPA Key Laboratory for Technology Research and Evaluation of Drug Products, and Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences; Department of Urology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China. [1] Shandong Key Laboratory of Targeted Drug Delivery and Advanced Pharmaceutics, NMPA Key Laboratory for Technology Research and Evaluation of Drug Products, and Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences; Department of Urology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China. wjing1@sdu.edu.cn. [2] Department of Neurosurgery, Qilu Hospital and Institute of Brain and Brain-Inspired Science, Cheeloo College of Medicine, Shandong University, Jinan, China. [3] Shandong Provincial Key Laboratory of Microparticles Drug Delivery Technology, Qilu Pharmaceutical Co., Ltd., Jinan, China. [4] State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China. jfzhang@nju.edu.cn. [5] Shandong Key Laboratory of Targeted Drug Delivery and Advanced Pharmaceutics, NMPA Key Laboratory for Technology Research and Evaluation of Drug Products, and Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences; Department of Urology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China. zhaofabao@email.sdu.edu.cn. [6] Department of Urology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. xingnianzeng@126.com. [7] Shandong Key Laboratory of Targeted Drug Delivery and Advanced Pharmaceutics, NMPA Key Laboratory for Technology Research and Evaluation of Drug Products, and Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences; Department of Urology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China. kzhao2013@sdu.edu.cn. [8] Shandong Key Laboratory of Targeted Drug Delivery and Advanced Pharmaceutics, NMPA Key Laboratory for Technology Research and Evaluation of Drug Products, and Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences; Department of Urology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China. xinyijiang@sdu.edu.cn. [9]
DOI 10.1038/s41587-026-03057-9
PMID 41826511
发布时间 2026-03-30
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