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Reactive astrocyte subpopulations with high Gfap and C4b expression in different Alzheimer's disease mouse models: Single-cell nuclear transcriptome analysis.

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第一作者： Congying,Huang

第一单位： Digital and Intelligent Empowerment Biomedical Innovation Center, School of Pharmacy, Shanghai University of Medicine and Health Sciences, Shanghai, China.;Shanghai Key Laboratory of Molecular Imaging, Zhoupu Hospital, Shanghai University of Medicine and Health Sciences, Shanghai, China.;School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, China.

作者： Congying,Huang ^[1] ; Yuru,Han ^[2] ; Jinjing,He ^[3] ; Wenhao,Ma ^[1] ; Yujia,Chen ^[4] ; Zhuo,Dong ^[5] ; Xiaoqin,Cheng ^[6] ; Changlian,Lu ^[2] ; Xuefeng,Gu ^[4]

作者单位： Digital and Intelligent Empowerment Biomedical Innovation Center, School of Pharmacy, Shanghai University of Medicine and Health Sciences, Shanghai, China.;Shanghai Key Laboratory of Molecular Imaging, Zhoupu Hospital, Shanghai University of Medicine and Health Sciences, Shanghai, China.;School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, China. ^[1] Shanghai Key Laboratory of Molecular Imaging, Zhoupu Hospital, Shanghai University of Medicine and Health Sciences, Shanghai, China. ^[2] Digital and Intelligent Empowerment Biomedical Innovation Center, School of Pharmacy, Shanghai University of Medicine and Health Sciences, Shanghai, China. ^[3] Digital and Intelligent Empowerment Biomedical Innovation Center, School of Pharmacy, Shanghai University of Medicine and Health Sciences, Shanghai, China.;Shanghai Key Laboratory of Molecular Imaging, Zhoupu Hospital, Shanghai University of Medicine and Health Sciences, Shanghai, China. ^[4] Coweldgen Scientific Co., Ltd., Shanghai, China. ^[5] Department of Neurology, Zhongshan Hospital, Fudan University, Shanghai, China. ^[6]

关键词 Alzheimer’s disease RNA RNA splicing astrocytes complement C4b disease models gene expression profiling glial fibrillary acidic protein hippocampus neurons single-cell analysis transcriptome

DOI 10.4103/NRR.NRR-D-25-00789

PMID 41837502

发布时间 2026-03-23

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Reactive astrocyte subpopulations with high Gfap and C4b expression in different Alzheimer's disease mouse models: Single-cell nuclear transcriptome analysis.

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Reactive astrocyte subpopulations with high Gfap and C4b expression in different Alzheimer's disease mouse models: Single-cell nuclear transcriptome analysis.

Neural regeneration research

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