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Drug-Metabolizing Enzymes in Human Keratinocytes and In Vitro Detection of Cytochrome P450-Mediated Phenolic Lamotrigine Metabolite.

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第一作者： Philipp N,Deck

第一单位： Research Division, Federal Institute for Drugs and Medical Devices (BfArM), Bonn 53175, Germany.;Pharmacology and Toxicology, Pharmaceutical Institute, University of Bonn, Bonn 53121, Germany.

作者： Philipp N,Deck ^[1] ; Mareike,Müller ^[1] ; Andreas,Glässner ^[2] ; Matthias,Vogel ^[3] ; Michael,Steffens ^[2] ; Caspar,Heubach ^[2] ; Guido,Fechner ^[4] ; Karl,Becker ^[5] ; Günther,Weindl ^[6] ; Bernhardt,Sachs ^[2]

作者单位： Research Division, Federal Institute for Drugs and Medical Devices (BfArM), Bonn 53175, Germany.;Pharmacology and Toxicology, Pharmaceutical Institute, University of Bonn, Bonn 53121, Germany. ^[1] Research Division, Federal Institute for Drugs and Medical Devices (BfArM), Bonn 53175, Germany. ^[2] Pharmacopoeia and Standard Licensing Division, Federal Institute for Drugs and Medical Devices (BfArM), Bonn 53175, Germany. ^[3] Department of Urology and Pediatric Urology, University Hospital Bonn, Bonn 53127, Germany. ^[4] Kinderchirurgische Gemeinschaftspraxis, Bonn 53113, Germany. ^[5] Pharmacology and Toxicology, Pharmaceutical Institute, University of Bonn, Bonn 53121, Germany. ^[6]

医学主题词人类(Humans);角蛋白细胞(Keratinocytes);细胞色素P450酶系统(Cytochrome P-450 Enzyme System);三嗪类(Triazines);细胞, 培养的(Cells, Cultured);酚类(Phenols)

DOI 10.1021/acs.chemrestox.5c00500

PMID 41910223

发布时间 2026-06-21

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