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Toward the simultaneous detection of multiple diseases with a highly cost-effective cell-free DNA methylome test.

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第一作者： Weihua,Zeng

第一单位： Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095.

作者： Weihua,Zeng ^[1] ; Chun-Chi,Liu ^[2] ; Shuo,Li ^[1] ; Yonggang,Zhou ^[1] ; Mary L,Stackpole ^[2] ; Ying,Xiao ^[2] ; Ran,Hu ^[1] ; Caitlin,Tang ^[1] ; Qiao,Liu ^[3] ; Wanwen,Zeng ^[3] ; Angela,Yeh ^[4] ; Andrew,Melehy ^[5] ; Benjamin,Tran ^[5] ; Zorawar,Noor ^[4] ; Megumi,Yokomizo ^[6] ; Dominic,Amara ^[5] ; Shreya,Gumate ^[5] ; Preeti,Ahuja ^[6] ; David Yuanze,Li ^[7] ; Junting,Zhao ^[8] ; Inga,Rose ^[9] ; Cattlena,Walker ^[10] ; Sadaf,Malik ^[10] ; Yazhen,Zhu ^[11] ; Hsian-Rong,Tseng ^[12] ; Edward B,Garon ^[13] ; Samuel W,French ^[11] ; Clara E,Magyar ^[11] ; Sarah M,Dry ^[11] ; Clara M,Lajonchere ^[14] ; Daniel,Geschwind ^[15] ; Gina,Choi ^[4] ; Sammy,Saab ^[4] ; Akshay,Shetty ^[4] ; Carrie R,Wong ^[16] ; Kevin G,King ^[6] ; David S,Lu ^[6] ; Steven S,Raman ^[6] ; Xiyan,Xiang ^[17] ; Kirti,Shetty ^[18] ; Lopa,Mishra ^[19] ; Sanaz,Memarzadeh ^[20] ; Yan,Liu ^[21] ; Frank,Alber ^[22] ; William,Hsu ^[23] ; Kostyantyn,Krysan ^[4] ; Steven M,Dubinett ^[24] ; Denise R,Aberle ^[25] ; Vatche,Agopian ^[26] ; Steven-Huy B,Han ^[13] ; Wing Hung,Wong ^[27] ; Xiaohui,Ni ^[2] ; Wenyuan,Li ^[1] ; Xianghong Jasmine,Zhou ^[28]

作者单位： Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095. ^[1] EarlyDiagnostics Inc., Agoura Hills, CA 91301. ^[2] Department of Statistics, Stanford University, Stanford, CA 94305. ^[3] Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095. ^[4] Department of Surgery, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095. ^[5] Department of Radiological Sciences, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095. ^[6] Thousand Oaks High School, Thousand Oaks, CA 91360. ^[7] Sage Hill School, Newport Coast, CA 92657. ^[8] Reference Medicine, Phoenix, AZ 85040. ^[9] Crown Bioscience, San Diego, CA 92127. ^[10] Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095.;Jonsson Comprehensive Cancer Center, University of California at Los Angeles, Los Angeles, CA 90095. ^[11] Jonsson Comprehensive Cancer Center, University of California at Los Angeles, Los Angeles, CA 90095.;Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095. ^[12] Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095.;Jonsson Comprehensive Cancer Center, University of California at Los Angeles, Los Angeles, CA 90095. ^[13] Jonsson Comprehensive Cancer Center, University of California at Los Angeles, Los Angeles, CA 90095.;Institute for Precision Health, University of California at Los Angeles, Los Angeles, CA 90095. ^[14] Institute for Precision Health, University of California at Los Angeles, Los Angeles, CA 90095. ^[15] Vatche and Tamar Manoukian Division of Digestive Diseases, Department of Medicine, University of California, Los Angeles, CA 90095. ^[16] The Institute for Bioelectronic Medicine, Feinstein Institutes for Medical Research and Cold Spring Harbor Laboratory, Department of Medicine, Division of Gastroenterology and Hepatology, Northwell Health, NY 11030. ^[17] Division of Gastroenterology and Hepatology, School of Medicine, University of Maryland, Baltimore, MD 21201. ^[18] The Institute for Bioelectronic Medicine, Feinstein Institutes for Medical Research and Cold Spring Harbor Laboratory, Department of Medicine, Division of Gastroenterology and Hepatology, Northwell Health, NY 11030.;Department of Surgery, George Washington University, Washington, DC 20037. ^[19] Jonsson Comprehensive Cancer Center, University of California at Los Angeles, Los Angeles, CA 90095.;Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095.;Department of Obstetrics and Gynecology, David Geffen School, University of California at Los Angeles, Los Angeles, CA 90095.;Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California Los Angeles, Los Angeles, CA 90095.;Molecular Biology Institute, University of California Los Angeles, Los Angeles, CA 90095.;The VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073. ^[20] Department of Computer Science, University of Southern California, Los Angeles, CA 90089. ^[21] Department of Microbiology, Immunology and Molecular Genetics, University of California at Los Angeles, Los Angeles, CA 90095.;Institute for Quantitative and Computational Biosciences, University of California at Los Angeles, Los Angeles, CA 90095. ^[22] Department of Radiological Sciences, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095.;Department of Bioengineering, Samueli School of Engineering, University of California at Los Angeles, Los Angeles, CA 90095. ^[23] Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095.;Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095.;Jonsson Comprehensive Cancer Center, University of California at Los Angeles, Los Angeles, CA 90095.;Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095.;The VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073. ^[24] Department of Radiological Sciences, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095.;Jonsson Comprehensive Cancer Center, University of California at Los Angeles, Los Angeles, CA 90095. ^[25] Department of Surgery, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095.;Jonsson Comprehensive Cancer Center, University of California at Los Angeles, Los Angeles, CA 90095. ^[26] Department of Statistics, Stanford University, Stanford, CA 94305.;Department of Biomedical Data Science, Stanford University, Stanford, CA 94305. ^[27] Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095.;Jonsson Comprehensive Cancer Center, University of California at Los Angeles, Los Angeles, CA 90095.;Institute for Quantitative and Computational Biosciences, University of California at Los Angeles, Los Angeles, CA 90095. ^[28]

关键词 DNA methylation cancer detection cell-free DNA disease detection liquid biopsy