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Synergistic induction of immunogenic cell death and tumor microenvironment remodeling by biotinylated marine polysaccharide nanoparticles for enhanced colorectal cancer therapy.

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第一作者： Hui,Wang

第一单位： CAS and Shandong Province Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, 266071, China; University of Chinese Academy of Sciences, Beijing, 100049, China.

作者： Hui,Wang ^[1] ; Haoyu,Yu ^[1] ; Yan,Yang ^[2] ; Mengying,Fu ^[1] ; Lihua,Geng ^[1] ; Jing,Wang ^[1] ; Yang,Yue ^[1] ; Quanbin,Zhang ^[1] ; Ning,Wu ^[3]

作者单位： CAS and Shandong Province Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, 266071, China; University of Chinese Academy of Sciences, Beijing, 100049, China. ^[1] CAS and Shandong Province Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, 266071, China. ^[2] CAS and Shandong Province Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, 266071, China; Laboratory for Marine Drugs and Bioproducts, Qingdao Marine Science and Technology Center, Qingdao, 266237, China; China Nantong Zhongke Marine Science and Technology Research and Development Center, China; University of Chinese Academy of Sciences, Beijing, 100049, China. Electronic address: wuning@qdio.ac.cn. ^[3]

关键词 Chitosan Dual-targeting Fucoidan Polysaccharide nanoparticles Tumor microenvironment