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An optimized protocol for efficient derivation of pancreatic islets from multiple human pluripotent stem cell lines.

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第一作者： Siqin,Wu

第一单位： Department of Clinical Sciences, Intervention and Technology, Karolinska Institutet, 171 77 Stockholm, Sweden; Gynecology and Reproductive Medicine, Karolinska Universitetssjukhuset, 141 86 Stockholm, Sweden; Spiber Technologies AB, AlbaNova University Center, 106 91 Stockholm, Sweden. Electronic address: siqinw@gmail.com.

作者： Siqin,Wu ^[1] ; Shivam,Chandel ^[2] ; Galyna,Bryzgalova ^[3] ; Paschalis,Efstathopoulos ^[4] ; Kelly,Blust ^[5] ; Cheng,Zhao ^[2] ; Eda,Erbil ^[2] ; Anna,Falk ^[6] ; My,Hedhammar ^[5] ; Per-Olof,Berggren ^[7] ; Fredrik,Lanner ^[2]

作者单位： Department of Clinical Sciences, Intervention and Technology, Karolinska Institutet, 171 77 Stockholm, Sweden; Gynecology and Reproductive Medicine, Karolinska Universitetssjukhuset, 141 86 Stockholm, Sweden; Spiber Technologies AB, AlbaNova University Center, 106 91 Stockholm, Sweden. Electronic address: siqinw@gmail.com. ^[1] Department of Clinical Sciences, Intervention and Technology, Karolinska Institutet, 171 77 Stockholm, Sweden; Gynecology and Reproductive Medicine, Karolinska Universitetssjukhuset, 141 86 Stockholm, Sweden. ^[2] The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, 171 76 Stockholm, Sweden. ^[3] Department of Clinical Sciences, Intervention and Technology, Karolinska Institutet, 171 77 Stockholm, Sweden; Gynecology and Reproductive Medicine, Karolinska Universitetssjukhuset, 141 86 Stockholm, Sweden; Spiber Technologies AB, AlbaNova University Center, 106 91 Stockholm, Sweden. ^[4] Division of Protein Technology, KTH Royal Institute of Technology, Roslagstullsbacken 21, 106 91 Stockholm, Sweden. ^[5] Department of Neuroscience, Karolinska Institutet, 171 65 Solna, Sweden; Neural Stem Cells, Department of Experimental Medical Science, Lund Stem Cell Center, Lund University, 221 84 Lund, Sweden. ^[6] The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, 171 76 Stockholm, Sweden. Electronic address: per-olof.berggren@ki.se. ^[7]

关键词 beta cells cell therapy cell-line variability diabetes differentiation protocol endocrine progenitors endocrine purity functional SC-islets human pluripotent stem cells intraocular transplantation