首页> NPJ vaccines> BPZE1 vaccination induces IL-17+ and IL-22+ CD4+ T cells associated with nasal mucosal secretory IgA responses in humans: effects on virulent Bordetella pertussis colonisation.

BPZE1 vaccination induces IL-17+ and IL-22+ CD4+ T cells associated with nasal mucosal secretory IgA responses in humans: effects on virulent Bordetella pertussis colonisation.

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第一作者： Alison R,Hill

第一单位： Controlled Human Infection Group, School of Clinical & Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.;NIHR Southampton Clinical Research Facility and Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK.

作者： Alison R,Hill ^[1] ; Diane F,Gbesemete ^[1] ; Tyween,Coutinho ^[2] ; Muktar,Ibrahim ^[2] ; Jay R,Laver ^[1] ; Peter,Goldstein ^[3] ; Stephanie,Noviello ^[3] ; Keith,Rubin ^[3] ; Saul N,Faust ^[4] ; Camille,Locht ^[5] ; Robert C,Read ^[1] ; Adam P,Dale ^[6]

作者单位： Controlled Human Infection Group, School of Clinical & Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.;NIHR Southampton Clinical Research Facility and Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK. ^[1] Controlled Human Infection Group, School of Clinical & Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK. ^[2] ILiAD Biotechnologies, Weston, FL, USA. ^[3] NIHR Southampton Clinical Research Facility and Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK.;Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK. ^[4] Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019-UMR9017-CIIL - Centre for Infection and Immunity of Lille, Lille, France. ^[5] Controlled Human Infection Group, School of Clinical & Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK. a.p.dale@soton.ac.uk.;NIHR Southampton Clinical Research Facility and Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK. a.p.dale@soton.ac.uk. ^[6]

DOI 10.1038/s41541-026-01443-7

PMID 42000798

发布时间 2026-04-18

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BPZE1 vaccination induces IL-17<sup>+</sup> and IL-22<sup>+</sup> CD4<sup>+</sup> T cells associated with nasal mucosal secretory IgA responses in humans: effects on virulent Bordetella pertussis colonisation.

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BPZE1 vaccination induces IL-17<sup>+</sup> and IL-22<sup>+</sup> CD4<sup>+</sup> T cells associated with nasal mucosal secretory IgA responses in humans: effects on virulent Bordetella pertussis colonisation.

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