换一批Lycorine suppresses DPP3-mediated Nrf2 signaling, thereby reducing SLC7A11 levels to trigger ferroptosis in colorectal cancer cells.
第一作者：
Juan,Sheng
第一单位：
Department of Gastroenterology, The Affiliated Hospital of Yunnan University, Kunming, 650021, China.
作者：
医学主题词
人类(Humans);石蒜科生物碱类(Amaryllidaceae Alkaloids);NF-E2相关因子2(NF-E2-Related Factor 2);结直肠肿瘤(Colorectal Neoplasms);动物(Animals);信号传导(Signal Transduction);菲啶类(Phenanthridines);小鼠, 裸(Mice, Nude);活性氧(Reactive Oxygen Species);细胞增殖(Cell Proliferation);小鼠(Mice);细胞系, 肿瘤(Cell Line, Tumor);HCT116细胞(HCT116 Cells);细胞凋亡(Apoptosis);小鼠, 近交BALB C(Mice, Inbred BALB C);抗肿瘤药, 植物(Antineoplastic Agents, Phytogenic)
DOI
10.1016/j.phymed.2026.158221
PMID
42048794
发布时间
2026-05-27
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Phytomedicine
158221页
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