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The density of tumour infiltrating lymphocytes in oesophago-gastric cancer varies with disease stage, geographical region and treatment: a post hoc analysis of nine phase III clinical trials.

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第一作者: Georgina A,Keogh
第一单位: Gastrointestinal and Lymphoma Unit, Royal Marsden NHS Foundation Trust, London, UK.
作者单位: Gastrointestinal and Lymphoma Unit, Royal Marsden NHS Foundation Trust, London, UK. [1] Department of Pathology, GROW - Research Institute for Oncology and Reproduction, Maastricht University Medical Center+, Maastricht, The Netherlands. [2] Department of Pathology, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan. [3] Department of Pathology, Center for Gastric Cancer, National Cancer Center, Goyang, Republic of Korea. [4] Division of Pathology and Data Analytics, Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK. [5] Department of Surgery, Royal Marsden NHS Foundation Trust, London, UK. [6] Department of Pathology, Kosin University Gospel Hospital, Busan, Republic of Korea. [7] Department of Surgery, Yonsei University College of Medicine, Seoul, Republic of Korea. [8] Department of Pathology, Wonju Severance Christian Hospital, Wonju-si, Gangwon-do, Republic of Korea. [9] Department of General, Visceral and Transplantation Surgery, University Hospital Essen, Essen, Germany.;Institute of Pathology, University Hospital Essen, Essen, Germany.;Department of Medicine 2 (Medical Faculty), RWTH Aachen University, Aachen, Germany.;Department of Pathology and Bioinformatics, Erasmus University Medical Center, Rotterdam, The Netherlands. [10] Pathology Department, Mid Yorkshire Hospitals NHS Trust, Wakefield, UK. [11] Department of Pathology, Chung-Ang University Hospital, Seoul, Republic of Korea. [12] Department of Pathology, Yonsei University College of Medicine, Seoul, Republic of Korea. [13] Department of Public Health & AI, National Cancer Center Graduate School of Cancer Science and Policy, and Center for Gastric Cancer and Department of Surgery, National Cancer Center, Goyang, Republic of Korea. [14] UCL Innovative Clinical Trials Unit, University College London, London, UK. [15] Department of Hospital Pathology, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea. [16] Waiv, Paris, France. [17] Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan. [18] Division of Cancer Research, School of Medicine, University of Dundee, Dundee, UK. [19] Department of General Surgery, Pancreatic Disease Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.;Research Institute of Pancreatic Diseases, Shanghai Key Laboratory of Translational Research for Pancreatic Neoplasms, Shanghai Jiao Tong University School of Medicine, Shanghai, China. [20] Center for Clinical and Translational Research, Kyushu University Hospital, Kyushu University, Fukuoka, Japan. [21] Department of Surgery, Fukuzawa Clinic, Yokohama, Japan. [22] Department of Internal Medicine, Division of Medical Oncology, GROW - Research Institute for Oncology and Reproduction, Maastricht University Medical Center+, Maastricht, The Netherlands. [23] Division of Pathology and Data Analytics, Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK.;Department of Histopathology, Leeds Teaching Hospitals NHS Trust, Leeds, UK. [24] Clinical Trials Research Unit, Leeds Institute of Clinical Trials Research, University of Leeds, Leeds, UK. [25] School of Computer Science, University of Leeds, Leeds, UK.;HeteroGenius Limited, Leeds, UK. [26] Department of Pathology, GROW - Research Institute for Oncology and Reproduction, Maastricht University Medical Center+, Maastricht, The Netherlands. h.grabsch@maastrichtuniversity.nl.;Division of Pathology and Data Analytics, Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK. h.grabsch@maastrichtuniversity.nl. [27]
DOI 10.1007/s10120-026-01739-6
PMID 42084815
发布时间 2026-07-07
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Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association

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