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Single-cell and spatial transcriptomic analyses of gene therapy-associated retinal inflammation in non-human primates.

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第一作者： Célia,Sourd

第一单位： Nuffield Laboratory of Ophthalmology, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, UK.

作者： Célia,Sourd ^[1] ; Joel,Quinn ^[1] ; Molly C,John ^[1] ; Cristina,Martinez-Fernandez de la Camara ^[2] ; Lakshanie C,Wickramasinghe ^[3] ; Moustafa,Attar ^[3] ; Hoda,Shamsnajafabadi ^[1] ; Ahmed,Salman ^[1] ; Sally A,Cowley ^[4] ; Calliope A,Dendrou ^[3] ; Robert E,MacLaren ^[2] ; Jasmina,Cehajic-Kapetanovic ^[2] ; Kanmin,Xue ^[5]

作者单位： Nuffield Laboratory of Ophthalmology, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, UK. ^[1] Nuffield Laboratory of Ophthalmology, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, UK.;Oxford University Hospitals NHS Foundation Trust, Oxford OX3 9DU, UK. ^[2] The Kennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, UK. ^[3] James and Lillian Martin Centre for Stem Cell Research, Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK. ^[4] Nuffield Laboratory of Ophthalmology, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, UK.;Oxford University Hospitals NHS Foundation Trust, Oxford OX3 9DU, UK.;Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3BH, UK. ^[5]

关键词 AAV gene therapy gene therapy-associated uveitis single-cell transcriptomic analysis spatial transcriptomics

DOI 10.1016/j.omta.2026.201726

PMID 42137601

发布时间 2026-05-15

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Molecular therapy. Advances

2026年34卷2期

201726页

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Molecular therapy. Advances

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Single-cell and spatial transcriptomic analyses of gene therapy-associated retinal inflammation in non-human primates.

Molecular therapy. Advances

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Single-cell and spatial transcriptomic analyses of gene therapy-associated retinal inflammation in non-human primates.

Molecular therapy. Advances

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Molecular therapy. Advances

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