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The competition between splicing and 3' processing shapes the human transcriptome.

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第一作者： Lindsey V,Soles

第一单位： Department of Microbiology and Molecular Genetics, School of Medicine, University of California, Irvine, Irvine, California 92617, USA.;Department of Molecular Biology and Genetics, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA.

作者： Lindsey V,Soles ^[1] ; Shuangyu,Li ^[2] ; Liang,Liu ^[2] ; Kristianna S K,Sarkan ^[3] ; Erik G,Alvstad ^[4] ; Lusong,Tian ^[2] ; Yoseop,Yoon ^[2] ; Marielle,Valdez ^[2] ; Ivan,Marazzi ^[4] ; Yongsheng,Shi ^[5]

作者单位： Department of Microbiology and Molecular Genetics, School of Medicine, University of California, Irvine, Irvine, California 92617, USA.;Department of Molecular Biology and Genetics, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA. ^[1] Department of Microbiology and Molecular Genetics, School of Medicine, University of California, Irvine, Irvine, California 92617, USA. ^[2] Department of Microbiology and Molecular Genetics, School of Medicine, University of California, Irvine, Irvine, California 92617, USA.;Department of Life and Environmental Sciences, Schmid College of Science and Technology, Chapman University, Orange, California 92866, USA. ^[3] Department of Biological Chemistry, School of Medicine, University of California, Irvine, Irvine, California 92617, USA. ^[4] Department of Microbiology and Molecular Genetics, School of Medicine, University of California, Irvine, Irvine, California 92617, USA; yongshes@uci.edu. ^[5]

关键词 cleavage and polyadenylation gene expression intronic polyadenylation pre-mRNA 3′ processing pre-mRNA processing pre-mRNA splicing transcription elongation transcription regulation

医学主题词人类(Humans);RNA剪接(RNA Splicing);多聚腺苷酸化(Polyadenylation);内含子(Introns);RNA3'端加工(RNA 3' End Processing);RNA前体(RNA Precursors)

DOI 10.1101/gad.353718.126

PMID 42140670

发布时间 2026-07-01

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