首页> Journal for immunotherapy of cancer> Pan-cancer analysis in the real-world setting uncovers immunogenomic drivers of acquired resistance post-immunotherapy.

Pan-cancer analysis in the real-world setting uncovers immunogenomic drivers of acquired resistance post-immunotherapy.

导出 LinkOut

翻译打印收藏纠错

第一作者： Mohamed Reda,Keddar

第一单位： Oncology Data Science and AI, Oncology R&D, AstraZeneca Cambridge Biomedical Campus, Cambridge, UK mohamedreda.keddar@astrazeneca.com.

作者： Mohamed Reda,Keddar ^[1] ; Sebastian,Carrasco Pro ^[2] ; Roy,Rabbie ^[3] ; Zeynep,Kalender Atak ^[4] ; Francesc,Muyas ^[5] ; Ana Camelo,Stewart ^[6] ; Scott A,Hammond ^[7] ; Doug C,Palmer ^[7] ; Ross,Stewart ^[8] ; Maureen,Carey ^[9] ; Kathleen,Burke ^[9] ; Ben,Sidders ^[10] ; Jessica,Davies ^[5] ; Jonathan R,Dry ^[9] ; Inigo,Martincorena ^[11] ; Sajan,Khosla ^[6] ; Adam,Schoenfeld ^[12] ; Martin L,Miller ^[13]

作者单位： Oncology Data Science and AI, Oncology R&D, AstraZeneca Cambridge Biomedical Campus, Cambridge, UK mohamedreda.keddar@astrazeneca.com. ^[1] Boehringer Ingelheim USA, Ridgefield, Connecticut, USA. ^[2] Late Development Oncology, AstraZeneca R&D Cambridge, Cambridge, UK. ^[3] Quotient Therapeutics, Cambridge, UK. ^[4] Oncology Data Science and AI, Oncology R&D, AstraZeneca, Barcelona, Spain. ^[5] Oncology Data Science and AI, Oncology R&D, AstraZeneca Cambridge Biomedical Campus, Cambridge, UK. ^[6] Oncology Research and Development, AstraZeneca, Gaithersburg, Maryland, USA. ^[7] AstraZeneca, Cambridge, Cambridgeshire, UK. ^[8] Tempus, Chicago, Illinois, USA. ^[9] Biorelate, Manchester, UK. ^[10] Wellcome Sanger Institute, Hinxton, UK. ^[11] Memorial Sloan Kettering Cancer Center, New York, New York, USA. ^[12] GSK R&D Stevenage, Stevenage, UK. ^[13]

关键词 Biomarker Breast Cancer Head and Neck Cancer Immune Checkpoint Inhibitor Lung Cancer

医学主题词人类(Humans);免疫疗法(Immunotherapy);抗药性, 肿瘤(Drug Resistance, Neoplasm);肿瘤(Neoplasms);肿瘤微环境(Tumor Microenvironment);女(雌)性(Female)

DOI 10.1136/jitc-2025-014321

PMID 42156138

发布时间 2026-05-19

翻译满意度评价：

准确一般字义偏差语意偏离译文作用小提交