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Discovery of a selective and effective CRBN-recruiting ATR degrader with strong antitumor activity.

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第一作者： Lei,Huang

第一单位： Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing, 211198, China; Department of Pharmacology and Medicinal Chemistry, Jiangsu Medical College, Yancheng, 224005, China.

作者： Lei,Huang ^[1] ; Chen,Shu ^[2] ; Wenwen,Lai ^[2] ; Yijia,Qiu ^[2] ; Xinran,Wang ^[2] ; Ping,Wei ^[3] ; Jiaxin,Xia ^[2] ; Yi,Zou ^[4] ; Qihua,Zhu ^[5] ; Shi,Shi ^[6]

作者单位： Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing, 211198, China; Department of Pharmacology and Medicinal Chemistry, Jiangsu Medical College, Yancheng, 224005, China. ^[1] Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing, 211198, China. ^[2] Hefei Institute of Pharmaceutical Industry Co. Ltd., Hefei, 230601, China. ^[3] Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing, 211198, China. Electronic address: zouyi@cpu.edu.cn. ^[4] Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing, 211198, China. Electronic address: zhuqihua@vip.126.com. ^[5] Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing, 211198, China. Electronic address: ss15195862158@163.com. ^[6]

关键词 ATR Anti-tumor activity DNA damage Kinase-independent PROTAC