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Disruption of carotenoid metabolism in cavefish via loss of beta-carotene oxygenase 2a.

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第一作者： David Peréz,Guerra

第一单位： Biology Department, University of Nevada, Reno, 1664 N Virginia Street, Reno, NV 89557, USA.

作者： David Peréz,Guerra ^[1] ; Sepalika,Bandara ^[2] ; Francisca,Leal ^[3] ; Hans,Vasquez-Gross ^[4] ; Juli,Petereit ^[4] ; Johannes,von Lintig ^[2] ; Misty R,Riddle ^[5]

作者单位： Biology Department, University of Nevada, Reno, 1664 N Virginia Street, Reno, NV 89557, USA. ^[1] Department of Pharmacology, School of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106, USA. ^[2] Department of Genetics, Blavatnik Institute, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA. ^[3] Nevada Bioinformatics Center, University of Nevada, Reno, 1664 N Virginia Street, Reno, NV 89557, USA. ^[4] Biology Department, University of Nevada, Reno, 1664 N Virginia Street, Reno, NV 89557, USA. Electronic address: mistyriddle@unr.edu. ^[5]

关键词 Astyanax mexicanus BCO2 beta-carotene oxygenase carotenoid accumulation carotenoid metabolism cavefish evolution evolutionary genetics metabolic evolution retinoid metabolism vitamin A metabolism

医学主题词动物(Animals);类胡萝卜素类(Carotenoids);氧合酶类(Oxygenases);维生素A(Vitamin A);鱼蛋白质类(Fish Proteins);突变(Mutation)

DOI 10.1016/j.cub.2026.05.003

PMID 42184829

发布时间 2026-06-13

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