换一批Structure-Guided Optimization of Novel Inhibitors of <i>Plasmodium</i> Lysyl-tRNA Synthetase with Multistage Activity against Malaria Parasites.
第一作者：
Barbara,Forte
第一单位：
Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.
作者：
Barbara,Forte [1]
;
Fiona,Bellany [1]
;
Peter S,Campbell [1]
;
Giulia,Chemi [1]
;
Alice,Dawson [1]
;
Mark,Anderson [1]
;
Yaw,Aniweh [2]
;
Anna Y,Burkhard [3]
;
Anna Caroline Campos,Aguiar [4]
;
Alisje,Churchyard [5]
;
Caitlin A,Cooper [6]
;
Amália,Dos Santos Ferreira [7]
;
Mufuliat Toyin,Famodimu [8]
;
Francis G,Fang [9]
;
Xiao,Hu [1]
;
Tonnie,Huijs [10]
;
Delphine,Baud [11]
;
Chimed,Jansen [1]
;
María Belén,Jiménez Díaz [12]
;
Roger,Bonnert [11]
;
Susan,Boyd [11]
;
Benigno,Crespo-Fernández [13]
;
Branko,Mitasev [9]
;
Simone,Montagna [1]
;
Sachel,Mok [14]
;
Dinakaran,Murugesan [1]
;
Sunil K,Narwal [3]
;
Neil R,Norcross [1]
;
John,Okombo [3]
;
Heekuk,Park [15]
;
Caroline,Peet [1]
;
Dhelio B,Pereira [16]
;
John M,Post [1]
;
Janette,Reader [17]
;
Jennifer,Riley [1]
;
David A,Robinson [1]
;
Raku,Shinkyo [9]
;
Frederick R C,Simeons [1]
;
Laura,Simpson [1]
;
Alasdair,Smith [1]
;
Dennis,Smith [11]
;
Josefine,Striepen [3]
;
Carolina B G,Teles [7]
;
Rianne,van der Laak [10]
;
Anne-Catrin,Uhlemann [15]
;
Amélie,Vantaux [18]
;
Caroline,Wilson [1]
;
Benoît,Witkowski [19]
;
Gavin,Wood [1]
;
Tomas,Yeo [3]
;
Fabio,Zuccotto [1]
;
Iñigo,Angulo-Barturen [12]
;
Jake,Baum [5]
;
Judith M,Bolscher [10]
;
Rafael Victorio Carvalho,Guido [19]
;
Lyn-Marié,Birkholtz [20]
;
Michael J,Delves [8]
;
Laurent,Dembele [21]
;
David A,Fidock [14]
;
Francisco Javier,Gamo [13]
;
Dennis E,Kyle [6]
;
Steven P,Maher [6]
;
Jean,Popovici [22]
;
Chris,Walpole [23]
;
Fabian,Gusovsky [9]
;
Paul A,Willis [11]
;
Kevin D,Read [1]
;
Ian H,Gilbert [1]
;
Beatriz,Baragaña [1]
作者单位：
Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.
[1]
West African Centre for Cell Biology of Infectious Pathogens (WACCBIP), College of Basic and Applied Sciences, University of Ghana, Accra LG54, Ghana.
[2]
Department of Microbiology & Immunology, Columbia University Irving Medical Center, New York, New York 10032, United States.;Center for Malaria Therapeutics and Antimicrobial Resistance, Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, New York 10032, United States.
[3]
Department of Microbiology, Immunology, and Parasitology, Federal University of São Paulo, São Paulo, São Paulo CEP 04023-062, Brazil.
[4]
Department of Life Sciences, Imperial College, London SW7 2AZ, U.K.
[5]
Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia 30602-0002, United States.
[6]
Oswaldo Cruz Foundation, Leishmaniasis and Malaria Bioassay Platform, Porto Velho, Rondônia CEP 76812-245, Brazil.
[7]
Department of Life Sciences, Imperial College, London SW7 2AZ, U.K.;Department of Infection Biology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, U.K.
[8]
Eisai, Inc., 35 Cambridge Park Drive Suite 200, Cambridge, Massachusetts 02140, United States.
[9]
TropIQ Health Sciences, Nijmegen 6534 AT, The Netherlands.
[10]
MMV Medicines for Malaria Venture, ICC, Geneva 1215, Switzerland.
[11]
The Art of Discovery, Derio 48160, Spain.
[12]
Global Health Medicines R&D, GSK, Tres Cantos, Madrid 28760, Spain.
[13]
Department of Microbiology & Immunology, Columbia University Irving Medical Center, New York, New York 10032, United States.;Center for Malaria Therapeutics and Antimicrobial Resistance, Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, New York 10032, United States.;Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, New York 10032, United States.
[14]
Center for Malaria Therapeutics and Antimicrobial Resistance, Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, New York 10032, United States.;Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, New York 10032, United States.
[15]
Research Center in Tropical Medicine of Rondônia, Porto Velho, Rondônia CEP 76812-329, Brazil.
[16]
Department of Biochemistry, Genetics and Microbiology, Institute for Sustainable Malaria Control University of Pretoria, Hatfield, Pretoria 0028, South Africa.
[17]
Malaria Molecular Epidemiology Unit, Institut Pasteur du Cambodge, Phnom Penh 120210, Cambodia.
[18]
São Carlos Institute of Physics, University of São Paulo, São Carlos, São Paulo CEP 13563-120, Brazil.
[19]
Department of Biochemistry, Stellenbosch University, Stellenbosch, Matieland 7602, South Africa.
[20]
Univerité Des Sciences, Des Techniques Et Des Technologies de Bamako (USTTB), Parasite and Microbe Research and Training Centre (P-MRTC), Faculty of Pharmacy, Point G, Bamako BP 1805, Mali.
[21]
Malaria Research Unit, Institut Pasteur du Cambodge, Phnom Penh 120210, Cambodia.;Infectious Disease Epidemiology and Analytics G5 Unit, Institut Pasteur, Université Paris Cité, Paris 75015, France.
[22]
Structural Genomics Consortium, Research Institute of the McGill University Health Centre, Montreal, Québec H4A 3J1, Canada.
[23]
医学主题词
动物(Animals);抗疟药(Antimalarials);赖氨酸tRNA连接酶(Lysine-tRNA Ligase);构效关系(Structure-Activity Relationship);恶性疟原虫(Plasmodium falciparum);人类(Humans);小鼠(Mice);疟疾(Malaria);酶抑制剂(Enzyme Inhibitors);小鼠, SCID(Mice, SCID);嘧啶类(Pyrimidines);疟原虫属(Plasmodium)
DOI
10.1021/acs.jmedchem.6c00823
PMID
42227818
发布时间
2026-06-13
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Journal of medicinal chemistry
Journal of medicinal chemistry
13820-13855页
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