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Differential Wnt/β-catenin signaling via TCF7L2/LEF1 binding specificity shapes cellular and tumor phenotypes.

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第一作者： Thomas A,Kluiver

第一单位： Princess Máxima Center for Pediatric Oncology, Utrecht 3584 CH, The Netherlands.

作者： Thomas A,Kluiver ^[1] ; Anna,Nordin ^[2] ; Yuyan,Lu ^[3] ; Xuan,Guo ^[1] ; Stephanie A,Schubert ^[1] ; Darien,Yeung ^[1] ; Arif Ibrahim,Ardisasmita ^[1] ; Wessel,Terpstra ^[1] ; Chang,Zhang ^[1] ; Xiaochen,Duan ^[1] ; Rishi,Savur ^[1] ; Marius C,van den Heuvel ^[4] ; Vincent E,de Meijer ^[4] ; Ruben H,de Kleine ^[4] ; Kathelijne,Kraal ^[1] ; Ronald R,de Krijger ^[1] ; József,Zsiros ^[1] ; Claudio,Cantù ^[2] ; Weng Chuan,Peng ^[1]

作者单位： Princess Máxima Center for Pediatric Oncology, Utrecht 3584 CH, The Netherlands. ^[1] Wallenberg Centre for Molecular Medicine, Linköping University, Linköping SE-581 83, Sweden.;Department of Biomedical and Clinical Sciences, Division of Molecular Medicine and Virology, Faculty of Medicine and Health Sciences, Linköping University, Linköping SE-581 83, Sweden.;Science for Life Laboratory, Linköping University, Linköping SE-581 83, Sweden. ^[2] Princess Máxima Center for Pediatric Oncology, Utrecht 3584 CH, The Netherlands.;Department of Oncology, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 361004, China. ^[3] Department of Surgery, Section of Hepatobiliary Surgery and Liver Transplantation, University of Groningen, University Medical Center Groningen, Groningen 9713 GZ, The Netherlands. ^[4]

关键词 TCF/LEF Wnt signaling cancer novel motif β-catenin