首页> Free radical biology & medicine> SIRT3 regulates PRDX3 acetylation to support mitochondrial peroxide detoxification and limit oxidative stress-associated ferroptosis vulnerability.

SIRT3 regulates PRDX3 acetylation to support mitochondrial peroxide detoxification and limit oxidative stress-associated ferroptosis vulnerability.

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第一作者： Tiange,Wang

第一单位： Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Department of Biochemistry and Molecular Cellular Biology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.

作者： Tiange,Wang ^[1] ; Jun,Tu ^[1] ; Xiangyun,Wei ^[1] ; Zi,Liang ^[1] ; Rong,Cai ^[1] ; Qiuju,Fan ^[1] ; Jianli,He ^[1] ; Tianshi,Wang ^[2] ; Jinke,Cheng ^[3]

作者单位： Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Department of Biochemistry and Molecular Cellular Biology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. ^[1] Department of Nephrology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China. ^[2] Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Department of Biochemistry and Molecular Cellular Biology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China; Hainan Academy of Medical Sciences, Haikou, Hainan, 571199, China. Electronic address: jkcheng@shsmu.edu.cn. ^[3]

关键词 Ferroptosis Lysine acetylation Mitochondrial peroxide detoxification Oxidative stress PRDX3 SIRT3

DOI 10.1016/j.freeradbiomed.2026.06.021

PMID 42276463

发布时间 2026-06-18

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