首页> Naunyn-Schmiedeberg's archives of pharmacology> Vitexin-loaded phytosomes protect against high-fat diet-induced MASLD modulating PI3K/AKT/mTOR/SREBP-1c, Nrf2/HO-1, NF-κB/COX-2, and apoptotic pathways.

Vitexin-loaded phytosomes protect against high-fat diet-induced MASLD modulating PI3K/AKT/mTOR/SREBP-1c, Nrf2/HO-1, NF-κB/COX-2, and apoptotic pathways.

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第一作者： Ahmed Ms,Hegazy

第一单位： Department of Anatomy, Faculty of Medicine, Northern Border University, 73213, Arar, Saudi Arabia.

作者： Ahmed Ms,Hegazy ^[1] ; Ayat B,Al-Ghafari ^[2] ; Huda A Al,Doghaither ^[3] ; Ekramy M,Elmorsy ^[4] ; Mazen M,Ghaith ^[5] ; Ahmad Najem,Alshammari ^[6] ; Mohamed G,Alfayoumi ^[7] ; Abeer M E,Hassan ^[8]

作者单位： Department of Anatomy, Faculty of Medicine, Northern Border University, 73213, Arar, Saudi Arabia. ^[1] Department of Biochemistry, Faculty of Science, King Abdulaziz University, 21589, Jeddah, Saudi Arabia.;Experimental Biochemistry Unit, King Fahd Medical Research Center, King Abdulaziz University, 21589, Jeddah, Saudi Arabia.;Editome: Precision Gene Editing Unit, King Fahd Medical Research Center, King Abdulaziz University, 21589, Jeddah, Saudi Arabia. ^[2] Department of Biochemistry, Faculty of Science, King Abdulaziz University, 21589, Jeddah, Saudi Arabia. ^[3] Center for Health Research, Northern Border University, P.O. Box 1321, 91431, Arar, Saudi Arabia. Ekramy.elmorsy@nbu.edu.sa. ^[4] Department of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia. ^[5] Department of Medical Laboratory Technology, College of Applied Medical Sciences, Northern Border University, 73213, Arar, Saudi Arabia. ^[6] General Department of Forensic Science and Criminology, Dubai Police General H. Q, Dubai, UAE. ^[7] Department of Medical Laboratory Technology, Faculty of Applied Health Sciences Technology6 of October City, University, October, Egypt. ^[8]

关键词 Apoptosis High-fat diet Inflammation Metabolic dysfunction-associated steatotic liver disease nonalcoholic steatohepatitis Oxidative stress Phytosomes Vitexin

DOI 10.1007/s00210-026-05576-3

PMID 42283841

发布时间 2026-06-12

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准确一般字义偏差语意偏离译文作用小提交