Variable effects of maturity-onset-diabetes-of-youth (MODY)-associated glucokinase mutations on substrate interactions and stability of the enzyme.
第一作者:
Y,Liang
第一单位:
Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia 19104, USA.
作者:
医学主题词
腺苷三磷酸(Adenosine Triphosphate);发病年龄(Age of Onset);动物(Animals);碱基序列(Base Sequence);DNA引物(DNA Primers);糖尿病, 2型(Diabetes Mellitus, Type 2);酶稳定性(Enzyme Stability);葡糖激酶(Glucokinase);谷胱甘肽转移酶(Glutathione Transferase);己糖激酶(Hexokinase);人类(Humans);胰岛(Islets of Langerhans);动力学(Kinetics);分子序列数据(Molecular Sequence Data);突变(Mutation);大鼠(Rats);重组融合蛋白质类(Recombinant Fusion Proteins);酿酒酵母菌(Saccharomyces cerevisiae);底物特异性(Substrate Specificity)
DOI
10.1042/bj3090167
PMID
7619052
发布时间
2022-04-09
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