The inhibition of antigen-induced eosinophilia and bronchoconstriction by CDP840, a novel stereo-selective inhibitor of phosphodiesterase type 4.
第一作者:
B,Hughes
第一单位:
Celltech Therapeutics Limited, Slough, Berkshire.
作者:
主题词
3',5'-环AMP磷酸二酯酶类(3',5'-Cyclic-AMP Phosphodiesterases);气道阻力(Airway Resistance);方差分析(Analysis of Variance);动物(Animals);哮喘(Asthma);苯甲酰胺类(Benzamides);支气管收缩(Bronchoconstriction);环核苷酸磷酸二酯酶类, 4型(Cyclic Nucleotide Phosphodiesterases, Type 4);疾病模型, 动物(Disease Models, Animal);剂量效应关系, 药物(Dose-Response Relationship, Drug);嗜酸粒细胞增多(Eosinophilia);豚鼠(Guinea Pigs);人类(Humans);白细胞介素5(Interleukin-5);同工酶类(Isoenzymes);肺(Lung);男(雄)性(Male);中性白细胞(Neutrophils);磷酸二酯酶抑制剂(Phosphodiesterase Inhibitors);磷酸二酯水解酶类(Phosphoric Diester Hydrolases);吡啶类(Pyridines);吡咯烷酮类(Pyrrolidinones);兔(Rabbits);大鼠(Rats);咯利普兰(Rolipram)
DOI
10.1111/j.1476-5381.1996.tb15522.x
PMID
8818342
发布时间
2019-05-12
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