p-Benzoquinone, a reactive metabolite of benzene, prevents the processing of pre-interleukins-1 alpha and -1 beta to active cytokines by inhibition of the processing enzymes, calpain, and interleukin-1 beta converting enzyme.
第一作者:
G F,Kalf
第一单位:
Department of Biochemistry and Molecular Pharmacology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107. IEA1347@tjuvm.tjuvm.edu
作者:
主题词
动物(Animals);苯(Benzene);苯醌类(Benzoquinones);骨髓(Bone Marrow);骨髓细胞(Bone Marrow Cells);卡配因(Calpain);半胱氨酸天冬氨酸蛋白酶1(Caspase 1);细胞系(Cell Line);半胱氨酸内肽酶类(Cysteine Endopeptidases);酶抑制剂(Enzyme Inhibitors);人类(Humans);吲哚美辛(Indomethacin);白细胞介素1(Interleukin-1);小鼠(Mice);蛋白质前体(Protein Precursors);蛋白质加工, 转译后(Protein Processing, Post-Translational);重组蛋白质类(Recombinant Proteins)
DOI
10.1289/ehp.961041251
PMID
9118901
发布时间
2018-11-13
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