Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally.
第一作者:
E E,Varfolomeev
第一单位:
Department of Biological Chemistry, The Weizmann Institute of Science, Rehovot, Israel.
作者:
主题词
动物(Animals);半胱氨酸天冬氨酸蛋白酶8(Caspase 8);半胱氨酸天冬氨酸蛋白酶9(Caspase 9);半胱氨酸天冬氨酸蛋白酶(Caspases);细胞死亡(Cell Death);细胞, 培养的(Cells, Cultured);半胱氨酸内肽酶类(Cysteine Endopeptidases);DNA, 互补(DNA, Complementary);死胎(Fetal Death);成纤维细胞(Fibroblasts);基因打靶(Gene Targeting);基因, 致死(Genes, Lethal);孕龄(Gestational Age);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 基因敲除(Mice, Knockout);表型(Phenotype);受体, 肿瘤坏死因子(Receptors, Tumor Necrosis Factor);受体, 肿瘤坏死因子, 成员25(Receptors, Tumor Necrosis Factor, Member 25);转录, 遗传(Transcription, Genetic)
DOI
10.1016/s1074-7613(00)80609-3
PMID
9729047
发布时间
2019-09-15
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