Siah-1 N-terminal RING domain is required for proteolysis function, and C-terminal sequences regulate oligomerization and binding to target proteins.
第一作者:
G,Hu
第一单位:
Division of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan.
作者:
医学主题词
动物(Animals);结合部位(Binding Sites);COS细胞(COS Cells);细胞黏附分子(Cell Adhesion Molecules);细胞系, 转化(Cell Line, Transformed);半胱氨酸内肽酶类(Cysteine Endopeptidases);内肽酶类(Endopeptidases);多酶复合物(Multienzyme Complexes);诱变(Mutagenesis);核蛋白质类(Nuclear Proteins);蛋白酶体内肽酶复合物(Proteasome Endopeptidase Complex);构效关系(Structure-Activity Relationship);肿瘤抑制蛋白质类(Tumor Suppressor Proteins);泛素蛋白连接酶类(Ubiquitin-Protein Ligases)
DOI
10.1128/MCB.19.1.724
PMID
9858595
发布时间
2025-01-03
基金项目
CA-70097/CA/NCI NIH HHS/United States
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