Structure-based bioisosterism design, synthesis and biological evaluation of novel 1,2,4-triazin-6-ylthioacetamides as potent HIV-1 NNRTIs

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作者： Zhan,P. ^[1] ; Li,X. ^[2] ; Li,Z. ; Chen,X. ; Tian,Y. ; Chen,W. ; Liu,X. ; Pannecouque,C. ; Clercq,E.D.

作者单位： Department of Medicinal Chemistry, Shandong University, Educational Ministry of China, No.44 ^[1] Rega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium ^[2]

关键词 1 2 4-Triazine Anti-HIV-1 activity Heterocycle HIV reverse transcriptase NNRTIs SAR Structure-based bioisosterism strategy Synthesis

发布时间 2013-11-20

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Bioorganic and Medicinal Chemistry Letters

2012年22卷23期

7155-7162页

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Structure-based bioisosterism design, synthesis and biological evaluation of novel 1,2,4-triazin-6-ylthioacetamides as potent HIV-1 NNRTIs

Bioorganic and Medicinal Chemistry Letters

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Bioorganic and Medicinal Chemistry Letters

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Structure-based bioisosterism design, synthesis and biological evaluation of novel 1,2,4-triazin-6-ylthioacetamides as potent HIV-1 NNRTIs

Bioorganic and Medicinal Chemistry Letters

相似文献

Bioorganic and Medicinal Chemistry Letters

相关期刊

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