Negative Cooperativity in the Interaction of Prostaglandin H Synthase-1 with the Competitive Inhibitor Naproxen Can Be Described as the Interaction of a Non-competitive Inhibitor with Heterogeneous Enzyme Preparation

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作者： Filimonov, I. S. ^[1] ; Berzova, A. P. ^[1] ; Barkhatov, V. I. ^[2] ; Krivoshey, A. V. ^[1] ; Trushkin, N. A. ^[1] ; Vrzheshch, P. V. ^[1]

作者单位： Lomonosov Moscow State Univ, Int Biotechnol Ctr, Moscow 119991, Russia ^[1] Lomonosov Moscow State Univ, Fac Bioengn & Bioinformat, Moscow 119991, Russia ^[2]

关键词 PGHS-1 COX-1 cyclooxygenase NSAIDs inhibitors naproxen Aleve kinetics cooperativity homodimer

发布时间 2019-05-01

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Biochemistry

2018年83卷2期

119-128页

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Negative Cooperativity in the Interaction of Prostaglandin H Synthase-1 with the Competitive Inhibitor Naproxen Can Be Described as the Interaction of a Non-competitive Inhibitor with Heterogeneous Enzyme Preparation

Biochemistry

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Negative Cooperativity in the Interaction of Prostaglandin H Synthase-1 with the Competitive Inhibitor Naproxen Can Be Described as the Interaction of a Non-competitive Inhibitor with Heterogeneous Enzyme Preparation

Biochemistry

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Biochemistry

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