Biarylpyrazole inverse agonists at the cannabinoid CB1 receptor: Importance of the C-3 carboxamide oxygen/lysine3.28(192) interaction

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作者： Hurst D ^[1] ; Umejiego U ^[2] ; Lynch D ^[3] ; Seltzman H ^[4] ; Hyatt S ; Roche M ; McAllister S ; Fleischer D ; Kapur A ; Abood M

作者单位： RTI Int, Chem & Life Sci, Res Triangle Pk, NC 27709 USA ^[1] Univ N Carolina, Dept Biochem & Chem, Ctr Drug Design, Greensboro, NC 27402 USA ^[2] Med Coll Georgia, Dept Pharmacol & Toxicol, Augusta, GA 30912 USA ^[3] Calif Pacific Med Ctr, Res Inst, San Francisco, CA 94107 USA ^[4]

关键词 BETA(2) ADRENERGIC-RECEPTOR PROTEIN-COUPLED RECEPTORS MOLECULAR MODELING INVESTIGATIONS INDUCED CONFORMATIONAL-CHANGES BIOLOGICAL-PROPERTIES ANTAGONIST SR141716A TRANSMEMBRANE DOMAIN LYSINE RESIDUE SR 141716A IONIC LOCK

发布时间 2013-11-20

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