Evolution of a highly selective and potent 2-(pyridin-2-yl)-1,3,5-triazine Tie-2 kinase inhibitor.

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作者： Hodous BL ^[1] ; Geuns-Meyer SD ; Hughes PE ; Albrecht BK ; Bellon S ; Bready J ; Caenepeel S ; Cee VJ ; Chaffee SC ; Coxon A ; Emery M ; Fretland J ; Gallant P ; Gu Y ; Hoffman D ; Johnson RE ; Kendall R ; Kim JL ; Long AM ; Morrison M ; Olivieri PR ; Patel VF ; Polverino A ; Ro

作者单位： Department of Medicinal Chemistry, Amgen Inc., One Kendall Square, Building 1000, Cambridge, Massachusetts 02139-1581, USA. bhodous@amgen.com (N-(2-((3-(dimethylamino)propyl)(methyl)amino)-5-(trifluoromethyl)phenyl)- 2-fluoro-5-(3-(4-(methylamino)-1, ^[1]

关键词 Angiogenesis Inhibitors Benzamides Pyridines Receptor TIE-2 Triazines 苯甲酰胺类吡啶类三嗪类

发布时间 2013-11-20

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