Loss of sirtuin 4 leads to elevated glucose- and leucine-stimulated insulin levels and accelerated age-induced insulin resistance in multiple murine genetic backgrounds

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作者： Huynh, Frank K. ^[1] ; Hu, Xiaoke ^[2] ; Lin, Zhihong ; Johnson, James D. ; Hirschey, Matthew D.

作者单位： Duke Univ, Med Ctr, Duke Mol Physiol Inst, 300 N Duke St, Durham, NC 27701 USA ^[1] Univ British Columbia, Life Sci Inst, Dept Cellular & Physiol Sci, Vancouver, BC V6T 1Z3, Canada ^[2]

关键词 Post-translational modifications Sirtuin Insulin resistance Insulin secretion Leucine SIRT4 NNT C57BL/6J C57BL/6NJ MGylation MGcylation HMGylation Acylation 3-methylglutarylation 3-methylglutaconylation 3-hydroxy-3-methylglutarylation

发布时间 2018-07-27

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Journal of inherited metabolic disease

2018年41卷1期

59-72页

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Loss of sirtuin 4 leads to elevated glucose- and leucine-stimulated insulin levels and accelerated age-induced insulin resistance in multiple murine genetic backgrounds

Journal of inherited metabolic disease

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Journal of inherited metabolic disease

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Loss of sirtuin 4 leads to elevated glucose- and leucine-stimulated insulin levels and accelerated age-induced insulin resistance in multiple murine genetic backgrounds

Journal of inherited metabolic disease

相似文献

Journal of inherited metabolic disease

相关期刊

检索历史清除