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PK/PD assessment in CNS drug discovery: Prediction of CSF concentration in rodents for P-glycoprotein substrates and application to in vivo potency estimation

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第一作者： Caruso,A.

作者： Caruso,A. ^[1] ; Alvarez-Sánchez,R. ; Hillebrecht,A. ; Poirier,A. ; Schuler,F. ; Lavé,T. ; Funk,C. ; Belli,S.

作者单位： F. Hoffmann-La Roche Ltd., Bldg. 70/151, Grenzacherstr. 124, CH 4070 Basel, Switzerland ^[1]

关键词 Cerebrospinal fluid In vitro-in vivo correlations P-glycoprotein substrates PK/PD assessment Unbound-brain concentration

发布时间 2013-11-20

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Biochemical Pharmacology

2013年85卷11期

1684-1699页

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Biochemical Pharmacology

2013年85卷11期

1684-1699页

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PK/PD assessment in CNS drug discovery: Prediction of CSF concentration in rodents for P-glycoprotein substrates and application to in vivo potency estimation

Biochemical Pharmacology

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PK/PD assessment in CNS drug discovery: Prediction of CSF concentration in rodents for P-glycoprotein substrates and application to in vivo potency estimation

Biochemical Pharmacology

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Biochemical Pharmacology

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