Design, synthesis and biological activity of new polyenolic inhibitors of matrix metalloproteinases: A focus on chemically-modified curcumins

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作者： Zhang,Y. ^[1] ; Gu,Y. ^[2] ; Lee,H.-M. ^[3] ; Hambardjieva,E. ^[4] ; Vranková,K. ; Golub,L.M. ; Johnson,F.

作者单位： Department of Oral Biology and Pathology, School of Dental Medicine, Stony Brook University, Stony ^[1] Department of Chemistry, Stony Brook University, Stony Brook, NY 11794-3400, United States ^[2] Department of General Dentistry, State University of New York at Stony Brook, Stony Brook, NY 11790 ^[3] Department of Pharmacological Sciences, State University of New York at Stony Brook, Stony Brook ^[4]

关键词 Chemically-modified-curcumin Connective tissue degradation Enolic β-diketone moiety Matrix metalloproteinases Zinc-binding

发布时间 2013-11-20

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