High-Throughput Agonist Shift Assay Development for the Analysis of M-1-Positive Allosteric Modulators

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作者： Homsher, Michelle F. ^[1] ; Beshore, Douglas C. ^[2] ; Cassaday, Jason ^[3] ; Squadroni, Brian ^[1] ; Mohammed, Elizabeth ^[1] ; Hartnett, Michelle ^[1] ; Day, Stephen ^[1] ; Ma, Lei ^[4] ; Pechter, David ^[5] ; Smith, Michelle D. ^[6] ; Monsma, Fredrick ^[1] ; Zuck, Paul ^[1] ; Finley, Michael F. ^[6] ; Uebele, Victor N. ^[1] ; Hermes, Jeffrey D. ^[1]

作者单位： Merck & Co Inc, Screening & Prot Sci, N Wales, PA USA ^[1] Merck & Co Inc, MRL Pipeline Support, Montreal, PQ, Canada ^[2] Merck Res Labs, Assay Operat, Kenilworth, NJ USA ^[3] Merck Res Labs, Discovery Chem, West Point, PA USA ^[4] Merck Res Labs, Neurosci, West Point, PA USA ^[5] Merck & Co Inc, In Vitro Pharmacol, Kenilworth, NJ USA ^[6]

关键词 agonist shift muscarinic M-1 PAM allostery allosteric modulator

发布时间 2018-01-14

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