Identification of the stereochemical requirements in the 4-aryl-2-cycloalkylidenhydrazinylthiazole scaffold for the design of selective human monoamine oxidase B inhibitors

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作者： D'Ascenzio,M. ^[1] ; Carradori,S. ^[2] ; Secci,D. ^[3] ; Mannina,L. ^[4] ; Sobolev,A.P. ^[5] ; DeMonte,C. ; Cirilli,R. ; Yá?ez,M. ; Alcaro,S. ; Ortuso,F.

作者单位： Istituto Superiore di Sanità, Dipartimento Del Farmaco, V.le Regina Elena 299, 00161 Rome, Italy ^[1] Dipartimento di Chimica e Tecnologie Del Farmaco, Sapienza University of Rome, P.le A. Moro 5 ^[2] Dipartimento di Scienze della Salute, 'Magna Graecia' University of Catanzaro, Campus Universitario ^[3] Departamento de Farmacología, Universidad de Santiago de Compostela, Campus Universitario sur, E ^[4] Istituto di Metodologie Chimiche, Laboratorio di Risonanza Magnetica 'Annalaura Segre', CNR, via ^[5]

关键词 Diastereoseparation Methylcyclopentane Molecular modeling Monoamine oxidase inhibitors Thiazole

发布时间 2014-10-24

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