Predictive pharmacokinetic-pharmacodynamic modeling of tumor growth after administration of an anti-angiogenic agent, bevacizumab, as single-agent and combination therapy in tumor xenografts

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作者： Rocchetti,M. ^[1] ; Germani,M. ^[2] ; DelBene,F. ^[3] ; Poggesi,I. ^[4] ; Magni,P. ^[5] ; Pesenti,E. ; DeNicolao,G.

作者单位： Via Tommaso Grossi 13, 20017 Rho MI, Italy ^[1] Pharmacokinetics and Modeling, Accelera S.r.l., Viale Pasteur 10, 20014 Nerviano MI, Italy ^[2] Dipartimento di Ingegneria Industriale e dell'Informazione, Universita' degli Studi di Pavia, Via ^[3] Pharmacology Department, Nerviano Medical Sciences, Viale Pasteur 10, 20014 Nerviano MI, Italy ^[4] Clinical Pharmacology/Advanced Modelling and Simulations, Janssen Pharmaceutical Companies of ^[5]

关键词 Additivity Combination therapy Mechanism-based model Model-based drug development Pharmacological interaction Tumor growth inhibition

发布时间 2013-11-20

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