Synergistic effects of functionally distinct substitutions in -lactamase variants shed light on the evolution of bacterial drug resistance

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作者： Patel, Meha P. ^[1] ; Hu, Liya ^[2] ; Brown, Cameron A. ^[3] ; Sun, Zhizeng ^[4] ; Adamski, Carolyn J. ; Stojanoski, Vlatko ; Sankaran, Banumathi ; Prasad, B. V. Venkataram ; Palzkill, Timothy

作者单位： Baylor Coll Med, Verna Marrs McLean Dept Biochem & Mol Biol, Houston, TX 77030 USA ^[1] Baylor Coll Med, Dept Pharmacol & Chem Biol, Houston, TX 77030 USA ^[2] Baylor Coll Med, Interdept Grad Program Translat Biol & Mol Med, Houston, TX 77030 USA ^[3] Lawrence Berkeley Natl Lab, Dept Mol Biophys & Integrated Bioimaging, Berkeley Ctr Struct Biol ^[4]

关键词 drug resistance enzyme kinetics enzyme catalysis protein evolution protein structure protein stability protein drug interaction conformational change antibiotic resistance -lactamase

发布时间 2019-06-06

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