Fragment-based identification and optimization of a class of potent pyrrolo[2,1-f][1,2,4]triazine MAP4K4 inhibitors

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作者： Wang, Lan ^[1] ; Stanley, Mark ^[2] ; Boggs, Jason W. ^[3] ; Crawford, Terry D. ^[4] ; Bravo, Brandon J. ^[5] ; Giannetti, Anthony M. ; Harris, Seth F. ; Magnuson, Steven R. ; Nonomiya, Jim ; Schmidt, Stephen ; Wu, Ping ; Ye, Weilan ; Gould, Stephen E. ; Murray, Lesley J. ; Ndubaku, Chudi O. ; Chen, Huifen

作者单位： Genentech Inc, Dept Discovery Chem, San Francisco, CA 94080 USA ^[1] Genentech Inc, Dept Biochem & Cellular Pharmacol, San Francisco, CA 94080 USA ^[2] Genentech Inc, Dept Biol Struct, San Francisco, CA 94080 USA ^[3] Genentech Inc, Dept Mol Oncol, San Francisco, CA 94080 USA ^[4] Genentech Inc, Dept Drug Metab & Pharmacokinet, San Francisco, CA 94080 USA ^[5]

关键词 MAP4K4 Fragment-based lead discovery Pyrrolotriazine Kinase inhibitors P-loop conformation

发布时间 2015-03-10

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