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Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization

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第一作者: Arking,D.E.
作者: Arking,D.E. [1] ; Pulit,S.L. [2] ; Crotti,L. [3] ; VanDerHarst,P. [4] ; Munroe,P.B. [5] ; Koopmann,T.T. [6] ; Sotoodehnia,N. [7] ; Rossin,E.J. [8] ; Morley,M. [9] ; Wang,X. [10] ; Johnson,A.D. [11] ; Lundby,A. [12] ; Gudbjartsson,D.F. [13] ; Noseworthy,P.A. [14] ; Eijgelsheim,M. [15] ; Bradford,Y. [16] ; Tarasov,K.V. [17] ; D?rr,M. [18] ; Müller-Nurasyid,M. [19] ; Lahtinen,A.M. [20] ; Nolte,I.M. [21] ; Smith,A.V. [22] ; Bis,J.C. [23] ; Isaacs,A. [24] ; Newhouse,S.J. [25] ; Evans,D.S. [26] ; Post,W.S. [27] ; Waggott,D. [28] ; Lyytik?inen,L.-P. [29] ; Hicks,A.A. [30] ; Eisele,L. [31] ; Ellinghaus,D. [32] ; Hayward,C. [33] ; Navarro,P. [34] ; Ulivi,S. [35] ; Tanaka,T. [36] ; Tester,D.J. [37] ; Chatel,S. [38] ; Gustafsson,S. [39] ; Kumari,M. [40] ; Morris,R.W. [41] ; Naluai,A.T. [42] ; Padmanabhan,S. [43] ; Kluttig,A. [44] ; Strohmer,B. [45] ; Panayiotou,A.G. [46] ; Torres,M. [47] ; Knoflach,M. [48] ; Hubacek,J.A. [49] ; Slowikowski,K. [50] ; Raychaudhuri,S. [51] ; Kumar,R.D. [52] ; Harris,T.B. [53] ; Launer,L.J. [54] ; Shuldiner,A.R. [55] ; Alonso,A. [56] ; Bader,J.S. [57] ; Ehret,G. [58] ; Huang,H. [59] ; Kao,W.H.L. [60] ; Strait,J.B. [61] ; Macfarlane,P.W. [62] ; Brown,M. [63] ; Caulfield,M.J. [64] ; Samani,N.J. [65] ; Kronenberg,F. [66] ; Willeit,J. [67] ; Smith,J.G. [68] ; Greiser,K.H. [69] ; ZuSchwabedissen,H.M. [70] ; Werdan,K. [71] ; Carella,M. [72] ; Zelante,L. [73] ; Heckbert,S.R. [74] ; Psaty,B.M. [75] ; Rotter,J.I. [76] ; Kolcic,I. [77] ; Pola?ek,O. [78] ; Wright,A.F. [79] ; Griffin,M. [80] ; Daly,M.J. [81] ; Arnar,D.O. [82] ; Hólm,H. [83] ; Thorsteinsdottir,U. [84] ; Denny,J.C. ; Roden,D.M. ; Zuvich,R.L. ; Emilsson,V. ; Plump,A.S. ; Larson,M.G. ; O'Donnell,C.J. ; Yin,X. ; Bobbo,M. ; D'Adamo,A.P. ; Iorio,A. ; Sinagra,G. ; Carracedo,A. ; Cummings,S.R. ; Nalls,M.A. ; Jula,A. ; Kontula,K.K. ; Marjamaa,A. ; Oikarinen,L. ; Perola,M. ; Porthan,K. ; Erbel,R. ; Hoffmann,P. ; J?ckel,K.-H. ; K?lsch,H. ; N?then,M.M. ; DenHoed,M. ; Loos,R.J.F. ; Thelle,D.S. ; Gieger,C. ; Meitinger,T. ; Perz,S. ; Peters,A. ; Prucha,H. ; Sinner,M.F. ; Waldenberger,M. ; DeBoer,R.A. ; Franke,L. ; VanDerVleuten,P.A. ; Beckmann,B.M. ; Martens,E. ; Bardai,A. ; Hofman,N. ; Wilde,A.A.M.
作者单位: Department of Pediatrics, Division of Pediatric Cardiology, Mayo Clinic, Rochester, MN, United [1] Laboratory of Neurogenetics, National Institute on Aging, US National Institutes of Health [2] Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech [3] Department of Medicine, University of Maryland, School of Medicine, Baltimore, MD, United States [4] Heart Failure Research Center, Department of Clinical and Experimental Cardiology, Academic Medical [5] Electrocardiology, University of Glasgow Institute of Cardiovascular and Medical Sciences, Royal [6] Chronic Disease Epidemiology and Prevention Unit, National Institute for Health and Welfare [7] Institute of Genetic Epidemiology, Helmholtz Zentrum Munich-German Research Center for [8] Department of Medicine I, University Hospital Munich, Ludwig Maximilians Universit?t, Munich [9] Medical Genetics Unit, Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy [10] Department of Cardiovascular Science, University of Leicester, Glenfield Hospital, Leicester [11] Broad Institute of MIT and Harvard, Cambridge, MA, United States, Computer Science and Artificial [12] Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam [13] Department of Public Health, Faculty of Medicine, University of Split, Split, Croatia [14] Institute of Cardiovascular Science, University College London, London, United Kingdom [15] Computational and Systems Biology Program, Division of Biology and Biomedical Sciences, Washington [16] Informatics and Biocomputing Platform, Ontario Institute for Cancer Research, Toronto, ON, Canada [17] Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala [18] BHF Glasgow Cardiovascular Research Centre, College of Medical, Veterinary and Life Sciences [19] Vascular Screening and Diagnostic Centre, London, United Kingdom [20] Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany, Institute of [21] Department of Neurology, Innsbruck Medical University, Innsbruck, Austria [22] Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany [23] Institute for Maternal and Child Health, Burlo Garofolo Trieste, Trieste, Italy, Clinical [24] Research Programs Unit, Molecular Medicine, University of Helsinki, Helsinki, Finland, Department [25] Christine Kühne-Center for Allergy and Education, Munich, Germany, Department of Dermatology and [26] Department of Clinical Genetics, Academic Medical Center, Amsterdam, Netherlands [27] Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, United States [28] Department of Medicine III, Medical Faculty, Martin Luther University Halle-Wittenberg, Halle [29] Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy [30] Department of Pharmacology, Ernst Moritz Arndt University of Greifswald, Greifswald, Germany [31] Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen [32] Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, Bethesda, MD [33] DZHK (German Centre for Cardiovascular Research), Partner site Munich Heart Alliance, Munich [34] Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen [35] Department of Medicine, University of Helsinki, Helsinki, Finland [36] Laboratory of Cardiovascular Sciences, Human Cardiovascular Studies Unit, National Institute on [37] Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, United States [38] Department of Epidemiology, Erasmus Medical Center, Rotterdam, Netherlands [39] Department of Clinical Chemistry, Fimlab Laboratories and University of Tampere, School of Medicine [40] Institute for Medical Informatics,Biometry and Epidemiology, University Hospital of Essen [41] Institute for Maternal and Child Health, Burlo Garofolo Trieste, Trieste, Italy [42] Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, United States [43] Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden [44] Cyprus International Institute for Environmental and Public Health in association, Harvard School [45] Medical Research Council (MRC) Human Genetics Unit, Institute of Genetics and Molecular Medicine [46] Center for Complex Disease Genomics, Johns Hopkins University, School of Medicine, Baltimore, MD [47] Icelandic Heart Association, Kopavogur, Iceland, Faculty of Medicine, University of Iceland [48] Institut du Thorax, Centre Hospitalier Universitaire de Nantes, Université de Nantes, Nantes [49] Cardiovascular Department, Ospedali Riuniti and University of Trieste, Trieste, Italy [50] Department of Medical and Clinical Genetics, Sahlgrenska Academy, University of Gothenburg [51] Department of Primary Care and Population Health, University College London, Royal Free Campus [52] Division of Epidemiology and Community Health, School of Public Health, University of Minnesota [53] Department of Biomedical Informatics, Vanderbilt University, School of Medicine, Nashville, TN [54] Department of Medicine, Division of Cardiology, Helsinki University Central Hospital, Helsinki [55] Institute for Biological and Medical Imaging, Helmholtz Zentrum München-German Research Center for [56] California Pacific Medical Center Research Institute, San Francisco, CA, United States [57] Grupo de Medicina Xenómica, Centro de Investigación Biomédica en Red de Enfermedades Raras [58] Clinical Pharmacology, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom [59] Public Health Genomics Unit, National Institute for Health and Welfare, Helsinki, Finland [60] Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA [61] Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany, DZHK [62] Department of Biostatistics, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway [63] MRC Epidemiology Unit, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom [64] Department of Epidemiology, Johns Hopkins University, Bloomberg School of Public Health, Baltimore [65] Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research [66] Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA [67] Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States [68] Center for Human Genetics Research, Vanderbilt University, School of Medicine, Nashville, TN [69] Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen [70] Clinical Pharmacology, Barts and the London School of Medicine, Queen Mary University of London [71] Sanofi Research and Development, Paris, France [72] Division of Cardiology, Johns Hopkins University, School of Medicine, Baltimore, MD, United States [73] Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United [74] Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for [75] Division of Genetic Epidemiology, Innsbruck Medical University, Innsbruck, Austria [76] Department of Medicine, Division of Cardiology, Landspitali University Hospital, Reykjavik, Iceland [77] Institute of Medical Epidemiology,Biostatistics and Informatics, Martin Luther University Halle [78] Icelandic Heart Association, Kopavogur, Iceland [79] Department of Molecular Medicine, Section of Cardiology, University of Pavia, Pavia, Italy, Center [80] Second Department of Internal Medicine, Paracelsus Medical University/Salzburger Landeskliniken [81] Department of Cardiology, University Hospital of Essen, University Duisburg-Essen, Essen, Germany [82] Department of Medicine, Vanderbilt University, School of Medicine, Nashville, TN, United States [83] National Heart,Lung,and Blood Institute (NHLBI) Framingham Heart Study, Framingham, MA, United [84]
发布时间 2016-04-19
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