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D-2-hydroxyglutarate produced by mutant IDH2 causes cardiomyopathy and neurodegeneration in mice

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第一作者: Akbay,E.A.
作者单位: Department of Physiology, University of Valencia, Burjassot, 46010 Valencia, Spain [1] Department of Microbiology and Immunobiology, Division of Immunology, Harvard Medical School [2] Department of Cell Biology, Dana-Farber Cancer Institute, Boston, MA 02215, United States [3] Division of Genomic Stability and DNA Repair, Department of Radiation Oncology, Dana-Farber Cancer [4] Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, United States [5] Cardiac Muscle Research Laboratory, Cardiovascular Division, Brigham and Women's Hospital, Harvard [6] Agios Pharmaceuticals, Cambridge, MA 02139, United States [7] Dana-Farber Cancer Institute, Boston, MA 02115, United States [8] Memorial Sloan Kettering Cancer Center, New York, NY 10065, United States [9] Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, United States [10] Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA 02114, United [11] Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston [12] Harvard Medical School, Boston, MA 02215, United States, Department of Cell Biology, Dana-Farber [13] Division of Signal Transduction, Beth Israel Deaconess Medical Center, Department of Medicine [14] Lurie Family Imaging Center, Dana- Farber Cancer Institute, Boston, MA 02215, United States [15] Belfer Institute for Applied Cancer Science, Dana Farber Cancer Institute, Boston, MA 02215, United [16] Department of Pediatrics, Columbia University Medical Center, New York, NY 10032, United States [17] Harvard Medical School, Boston, MA 02215, United States, Division of Genomic Stability and DNA [18] Harvard Medical School, Boston, MA 02215, United States, Massachusetts General Hospital Cancer [19]
发布时间 2014-05-29
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Genes and Development: a Journal Devoted to the Molecular Analysis of Gene Expression in Eukaryotes, Prokaryotes, and Viruses

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