Gut microbiota metabolizes nabumetone in vitro: Consequences for its bioavailability in vivo in the rodents with altered gut microbiome

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作者： Jourova, Lenka ^[1] ; Anzenbacher, Pavel ^[2] ; Matuskova, Zuzana ^[3] ; Vecera, Rostislav ^[4] ; Strojil, Jan ^[5] ; Kolar, Milan ^[6] ; Nobilis, Milan ; Hermanova, Petra ; Hudcovic, Tomas ; Kozakova, Hana ; Kverka, Miloslav ; Anzenbacherova, Eva

作者单位： Palacky Univ Olomouc, Fac Med & Dent, Dept Pharmacol, Olomouc, Czech Republic ^[1] Palacky Univ Olomouc, Fac Med & Dent, Dept Med Chem & Biochem, Olomouc, Czech Republic ^[2] Czech Acad Sci, Inst Microbiol, Prague, Czech Republic ^[3] Palacky Univ Olomouc, Fac Med & Dent, Dept Microbiol, Olomouc, Czech Republic ^[4] Charles Univ Prague, Fac Pharm Hradec Kralove, Dept Pharmaceut Chem & Drug Control, Hradec Kralove ^[5] Czech Acad Sci, Inst Microbiol, Novy Hradek, Czech Republic ^[6]

关键词 Gut microbiome pharmacokinetic of nabumetone imipenem germ-free mice bioavailability metabolism of drugs

发布时间 2020-11-17

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