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Growth arrest by the antitumor steroidal lactone withaferin a in human breast cancer cells is associated with down-regulation and covalent binding at cysteine 303 of β-tubulin

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作者单位: Biomolecular Structure Section, Center for Cancer Research, NCI, Frederick, MD 21702, United States [1] Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, United States [2] Departments of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine [3] Biomedical Mass Spectrometry Center, University of Pittsburgh School of Medicine, Pittsburgh, PA [4] Department of Hematology and Medical Oncology, Emory University, Atlanta, GA 30322, United States [5] Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA [6]
发布时间 2014-12-20
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The Journal of biological chemistry

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