Genetic toxicity testing using human in vitro organotypic airway cultures: Assessing DNA damage with the CometChip and mutagenesis by Duplex Sequencing

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作者： Wang, Yiying ^[1] ; Mittelstaedt, Roberta A. ^[2] ; Wynne, Rebecca ^[3] ; Chen, Ying ^[4] ; Cao, Xuefei ; Muskhelishvili, Levan ; Davis, Kelly ; Robison, Timothy W. ; Sun, Wei ; Schmidt, Elizabeth K. ; Smith, Thomas H. ; Norgaard, Zachary K. ; Valentine, Charles C. ; Yaplee, Jeffry ; Williams, Lindsey N. ; Salk, Jesse J. ; Heflich, Robert H.

作者单位： US FDA, Natl Ctr Toxicol Res, Jefferson, AR 72079 USA ^[1] Toxicol Pathol Associates, Jefferson, AR USA ^[2] US FDA, Ctr Drug Evaluat & Res, Silver Spring, MD USA ^[3] Twinstrand Biosci Inc, Seattle, WA USA ^[4]

关键词 DNA damage error-corrected next generation sequencing (ecNGS)ethyl methanesulfonate (EMS)human in vitro air-liquid-interface (ALI) airway epithelial tissue model mutagenesis

发布时间 2021-08-05

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