Time-dependent inhibition of CYP3A4-mediated midazolam metabolism by macrolide antibiotics in CYP3A4 genetic variants: Comparison with testosterone metabolism-论文-万方医学网

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Time-dependent inhibition of CYP3A4-mediated midazolam metabolism by macrolide antibiotics in CYP3A4 genetic variants: Comparison with testosterone metabolism

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第一作者： Akiyoshi, Takeshi

作者： Akiyoshi, Takeshi ^[1] ; Naitou, Rina ^[2] ; Imaoka, Ayuko ^[3] ; Miyazaki, Mitsue ^[4] ; Guengerich, F. Peter ; Nakamura, Katsunori ; Yamamoto, Koujiro ; Ohtani, Hisakazu

作者单位： Fac Pharmaceut Sci,Keio Univ ^[1] Grad Sch Med,Gunma Univ ^[2] Sch Med,Vanderbilt Univ ^[3] Dept Pharm,Ryukyus Univ Hosp ^[4]

关键词 erythromycin clarithromycin mechanism-based inhibition CYP3A4 genetic variants time-dependent inhibition RECOMBINANT CYTOCHROMES P450 MECHANISM-BASED INHIBITION IN-VITRO STRUCTURAL BASIS BINDING-SITES 3A4 OXIDATION PREDICTION ERYTHROMYCIN DIAZEPAM

发布时间 2022-10-29

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Time-dependent inhibition of CYP3A4-mediated midazolam metabolism by macrolide antibiotics in CYP3A4 genetic variants: Comparison with testosterone metabolism

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Time-dependent inhibition of CYP3A4-mediated midazolam metabolism by macrolide antibiotics in CYP3A4 genetic variants: Comparison with testosterone metabolism

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