Discovery of Highly Potent p53-MDM2 Antagonists and Structural Basis for Anti-Acute Myeloid Leukemia Activities

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作者： Yijun Huang ^[1] ; Siglinde Wolf ^[2] ; Barbara Beck ^[3] ; Lisa-Maria Ko?hler ^[4] ; Kareem Khoury ^[5] ; Grzegorz M. Popowicz ; Sayed K Goda ; Marion Subklewe ; Aleksandra Twarda ; Tad A. Holak ; Alexander Do?mling

作者单位： Protein Engineering Unit, Anti-Doping Laboratory-Qatar, Doha, Qatar ^[1] Clinical Cooperation Group Immunotherapy, Helmholtz Zentrum Mu?nchen, Marchioninistrasse 25, 81377 Mu?nchen, Germany ^[2] Faculty of Chemistry, Jagiellonian University, Ingardena 3, 30-060 Cracow, Poland ^[3] Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, 3501 Fifth Avenue, Pittsburgh, Pennsylvania 15261, United States ^[4] Max Plank Institute for Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany ^[5]

关键词 Discovery of Highly Potent Antagonists and Structural Basis Anti-Acute Myeloid Leukemia Activities

发布时间 2014-07-31

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