Discovery of novel 2-(3-(2-chlorophenyl)pyrazin-2-ylthio)-N-arylacetamides as potent HIV-1 inhibitors using a structure-based bioisosterism approach

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作者： Zhan,P. ^[1] ; Chen,W. ^[2] ; Li,Z. ; Li,X. ; Chen,X. ; Tian,Y. ; Pannecouque,C. ; Clercq,E.D. ; Liu,X.

作者单位： Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University, 44, West ^[1] Rega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium ^[2]

关键词 Anti-HIV-1 activity Heterocycle HIV reverse transcriptase NNRTIs Pyrazinylthioacetamide SAR Structure-based bioisosterism strategy Synthesis

发布时间 2013-11-20

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Bioorganic and medicinal chemistry

2012年20卷23期

6795-6802页

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Discovery of novel 2-(3-(2-chlorophenyl)pyrazin-2-ylthio)-N-arylacetamides as potent HIV-1 inhibitors using a structure-based bioisosterism approach

Bioorganic and medicinal chemistry

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Bioorganic and medicinal chemistry

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Discovery of novel 2-(3-(2-chlorophenyl)pyrazin-2-ylthio)-N-arylacetamides as potent HIV-1 inhibitors using a structure-based bioisosterism approach

Bioorganic and medicinal chemistry

相似文献

Bioorganic and medicinal chemistry

相关期刊

检索历史清除