Dose-dependent effects of R-sulforaphane isothiocyanate on the biology of human mesenchymal stem cells, at dietary amounts, it promotes cell proliferation and reduces senescence and apoptosis, while at anti-cancer drug doses, it has a cytotoxic effect

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作者： Zanichelli,F. ^[1] ; Capasso,S. ^[2] ; Cipollaro,M. ^[3] ; Pagnotta,E. ^[4] ; Cartenì,M. ; Casale,F. ; Iori,R. ; Galderisi,U.

作者单位： Consiglio Per la Ricerca e la Sperimentazione in Agricoltura (C.R.A.), Industrial Crop Research ^[1] Department of Experimental Medicine, Biotechnology and Molecular Biology Section, Second University ^[2] Department of Pediatrics F. Fede, Second University of Naples, Naples, Italy ^[3] Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, Temple ^[4]

关键词 Apoptosis Cell cycle Differentiation Histone deacetylase Isothiocyanate Marrow stromal stem cells Senescence

发布时间 2013-11-20

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