Synthesis and biological evaluation of N-aryl-7-methoxybenzo[b]furo[3,2-d] pyrimidin-4-amines and their N-arylbenzo[b]thieno[3,2-d]pyrimidin-4-amine analogues as dual inhibitors of CLK1 and DYRK1A kinases

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作者： Loidreau,Y. ^[1] ; Marchand,P. ^[2] ; Dubouilh-Benard,C. ^[3] ; Nourrisson,M.-R. ^[4] ; Duflos,M. ; Loa?c,N. ; Meijer,L. ; Besson,T.

作者单位： Université de Nantes, Nantes Atlantique Universités, UFR des Sciences Pharmaceutiques et ^[1] Manros Therapeutics, Centre de Perharidy, 29680 Roscoff, France ^[2] Protein Phosphorylation and Human Disease Group, Station Biologique, 29680 Roscoff, France, Manros ^[3] Université de Rouen, Laboratoire de Chimie Organique et Bio-organique, Institut de Recherche en ^[4]

关键词 Alzheimer's disease Benzo[b]furo[3 2-d]pyrimidin-4-amines Benzo[b]thieno[3 CLK DYRK Kinase inhibitors Microwave-assisted chemistry

发布时间 2013-11-20

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European Journal of Medicinal Chemistry

2013年59卷

283-295页

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Synthesis and biological evaluation of N-aryl-7-methoxybenzo[b]furo[3,2-d] pyrimidin-4-amines and their N-arylbenzo[b]thieno[3,2-d]pyrimidin-4-amine analogues as dual inhibitors of CLK1 and DYRK1A kinases

European Journal of Medicinal Chemistry

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European Journal of Medicinal Chemistry

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Synthesis and biological evaluation of N-aryl-7-methoxybenzo[b]furo[3,2-d] pyrimidin-4-amines and their N-arylbenzo[b]thieno[3,2-d]pyrimidin-4-amine analogues as dual inhibitors of CLK1 and DYRK1A kinases

European Journal of Medicinal Chemistry

相似文献

European Journal of Medicinal Chemistry

相关期刊

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