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Activating p53 family member TAp63: A novel therapeutic strategy for targeting p53‐altered tumors

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第一作者： Gunaratne Preethi H.

作者： Gunaratne Preethi H. ^[1] ; Pan Yinghong ^[2] ; Rao Abhi K. ^[3] ; Lin Chunru ^[4] ; Hernandez‐Herrera Anadulce ^[5] ; Liang Ke ^[6] ; Rait Antonina S. ^[7] ; Venkatanarayan Avinashnarayan ^[8] ; Benham Ashley L. ^[9] ; Rubab Farwah ; Kim Sang Soo ; Rajapakshe Kimal ; Chan Clara K. ; Mangala Lingegowda S. ; Lopez‐Berestein Gabriel ; Sood Anil K. ; Rowat Amy C. ; Coarfa Cristian ; Pirollo Kathleen F. ; Flores Elsa R. ; Chang Esther H.

作者单位： SynerGene Therapeutics, Inc.Potomac,Maryland ^[1] Gynecologic Oncology and Reproductive MedicineThe University of Texas MD Anderson Cancer ^[2] Department of Molecular and Cellular Oncology, Division of Basic ScienceThe University of Texas MD ^[3] Center for RNAi and Non-Coding RNAsThe University of Texas MD Anderson Cancer CenterHouston,Texas ^[4] Department of Molecular and Cell BiologyBaylor College of MedicineHouston,Texas ^[5] Department of Biochemistry and BiologyUniversity of HoustonHouston,Texas ^[6] Lester and Sue Smith Breast CenterBaylor College of MedicineHouston,Texas ^[7] Department of Integrative Biology and PhysiologyUniversity of CaliforniaLos Angeles,California ^[8] Department of Oncology, Lombardi Comprehensive Cancer CenterGeorgetown UniversityWashington ^[9]

关键词 3‐dimensional (3D) spheroids B‐cell lymphoma 2‐like protein 11 ( BIM )chemosensitization cisplatin leoyl‐sn‐glycero‐3‐phosphatidylcholine (DOPC)microRNA 130b (miR‐130b)ovarian cancer transactivation (TA) and N‐terminally truncated (ΔN) isoforms of the p63 protein ( TAp63/ΔNp63 )tumor protein p53 tumor‐targeted nanocomplex (scL)

发布时间 2019-12-12

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