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2-(2-Phenylmorpholin-4-yl)pyrimidin-4(3H)-ones; A new class of potent, selective and orally active glycogen synthase kinase-3β inhibitors

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第一作者： Fukunaga,K.

作者： Fukunaga,K. ^[1] ; Uehara,F. ^[2] ; Aritomo,K. ^[3] ; Shoda,A. ^[4] ; Hiki,S. ^[5] ; Okuyama,M. ^[6] ; Usui,Y. ^[7] ; Watanabe,K. ^[8] ; Yamakoshi,K. ; Kohara,T. ; Hanano,T. ; Tanaka,H. ; Tsuchiya,S. ; Sunada,S. ; Saito,K.-I. ; Eguchi,J.-I. ; Yuki,S. ; Asano,S. ; Tanaka,S. ; Mori,A. ; Yamagami,K. ; Baba,H. ; Horikawa,T. ; Fujimura,M.

作者单位： Mitsubishi Tanabe Pharma Corporation, Kamoshida-cho, Aoba-ku, Yokohama 227-0033, Japan ^[1] Mitsubishi Tanabe Pharma Corporation, Kamoshida-cho, Aoba-ku, Yokohama 227-0033, Japan, Mitsubishi ^[2] Mitsubishi Tanabe Pharma Corporation, Kamoshida-cho, Aoba-ku, Yokohama 227-0033, Japan, Development ^[3] Mitsubishi Tanabe Pharma Corporation, Kamoshida-cho, Aoba-ku, Yokohama 227-0033, Japan, Research ^[4] Mitsubishi Tanabe Pharma Corporation, Kamoshida-cho, Aoba-ku, Yokohama 227-0033, Japan, KAITEKI ^[5] Mitsubishi Tanabe Pharma Corporation, Kamoshida-cho, Aoba-ku, Yokohama 227-0033, Japan, National ^[6] Mitsubishi Tanabe Pharma Corporation, Kamoshida-cho, Aoba-ku, Yokohama 227-0033, Japan, Global ^[7] Mitsubishi Tanabe Pharma Corporation, Kamoshida-cho, Aoba-ku, Yokohama 227-0033, Japan, Tanabe ^[8]

关键词 Alzheimer's disease Glycogen synthase kinase-3β Hyperphosphorylation Tau protein

发布时间 2014-03-12

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